Which describes the second phase of primary TB infection?

Which describes the second phase of primary TB infection?

• A. Latent TB Infection (LTBI) / Formation of Ghon Complex
• B. Progressive TB / Active Disease
• C. Early Generalization Miliary TB
• D. Cavitary TB

Answer: (A)

Latent TB infection follows the initial primary infection and is defined by containment of the bacilli with formation of a Ghon complex in the lung and regional lymph nodes. After inhalation, the bacteria form a Ghon focus and enlist nearby lymph nodes; together these lesions are called the Ghon complex. When the immune system walls off the infection, the bacilli become dormant, producing latent TB infection. This phase is asymptomatic and generally not contagious, though a positive TB test may indicate prior exposure. Reactivation or progression to active disease can occur later if immunity wanes, but in this phase the infection is effectively contained rather than spreading.

Latent TB infection follows the initial primary infection and is defined by containment of the bacilli with formation of a Ghon complex in the lung and regional lymph nodes. After inhalation, the bacteria form a Ghon focus and enlist nearby lymph nodes; together these lesions are called the Ghon complex. When the immune system walls off the infection, the bacilli become dormant, producing latent TB infection. This phase is asymptomatic and generally not contagious, though a positive TB test may indicate prior exposure. Reactivation or progression to active disease can occur later if immunity wanes, but in this phase the infection is effectively contained rather than spreading.