What is recommended for patients with severe Campylobacter infection?

What is recommended for patients with severe Campylobacter infection?

• A. Azithromycin
• B. Ceftriaxone
• C. Doxycycline
• D. Penicillin

Answer: (A)

When severe Campylobacter infection occurs, antibiotics are used to shorten illness and prevent complications, with macrolides recommended as first-line therapy. Azithromycin is favored because Campylobacter jejuni often shows resistance to fluoroquinolones, and macrolides provide reliable activity with good tissue penetration and tolerability. Its oral or IV options make it practical for varying illness severities. Other drugs listed—ceftriaxone, penicillin, and doxycycline—do not have reliable activity against Campylobacter in this context, so they are not the preferred choices for severe infection.

When severe Campylobacter infection occurs, antibiotics are used to shorten illness and prevent complications, with macrolides recommended as first-line therapy. Azithromycin is favored because Campylobacter jejuni often shows resistance to fluoroquinolones, and macrolides provide reliable activity with good tissue penetration and tolerability. Its oral or IV options make it practical for varying illness severities. Other drugs listed—ceftriaxone, penicillin, and doxycycline—do not have reliable activity against Campylobacter in this context, so they are not the preferred choices for severe infection.