MDROs frequently identified in ICU CLABSI include which combination?

MDROs frequently identified in ICU CLABSI include which combination?

• A. Staphylococcus aureus including MRSA
• B. Acinetobacter baumannii and Vancomycin-Resistant Enterococcus (VRE)
• C. Streptococcus pneumoniae
• D. Escherichia coli

Answer: (B)

In ICUCLABSI, infections linked to central lines are often caused by organisms that survive well in hospital settings and resist multiple drugs. Acinetobacter baumannii is a notorious ICU pathogen that spreads easily, persists on surfaces, and frequently shows multidrug resistance, leading to challenging bloodstream infections in critically ill patients. Vancomycin-resistant Enterococcus (VRE) is another hospital-adapted MDRO that can colonize the GI tract and skin and cause bacteremia in patients with prolonged ICU stays and broad-spectrum antibiotic exposure. Together, these two organisms reflect the antimicrobial resistance patterns and the ICU environment that make device-associated bloodstream infections particularly hard to treat. While other pathogens like MRSA can cause CLABSI and some E. coli or Streptococcus pneumoniae can appear in hospital settings, the combination of Acinetobacter baumannii and VRE is the classic pair most frequently identified as MDROs in ICU CLABSI.

In ICUCLABSI, infections linked to central lines are often caused by organisms that survive well in hospital settings and resist multiple drugs. Acinetobacter baumannii is a notorious ICU pathogen that spreads easily, persists on surfaces, and frequently shows multidrug resistance, leading to challenging bloodstream infections in critically ill patients. Vancomycin-resistant Enterococcus (VRE) is another hospital-adapted MDRO that can colonize the GI tract and skin and cause bacteremia in patients with prolonged ICU stays and broad-spectrum antibiotic exposure. Together, these two organisms reflect the antimicrobial resistance patterns and the ICU environment that make device-associated bloodstream infections particularly hard to treat. While other pathogens like MRSA can cause CLABSI and some E. coli or Streptococcus pneumoniae can appear in hospital settings, the combination of Acinetobacter baumannii and VRE is the classic pair most frequently identified as MDROs in ICU CLABSI.